Syed Ameer Ali was a lawyer, a judge, a political and social reformer, and a scholar of Islam. He wrote a number of books on Islamic law. He first arrived in the UK in 1869 initially to compete for the ICS. He was friends with the Fawcetts and attended female suffrage meetings in 1870. He was called to the Bar through the Inner Temple and returned to India to serve in the Calcutta High Court.

Syed Ameer Ali made frequent returns to Britain after 1873. In 1880 he met James Knowles, editor of The Nineteenth Century, and thereafter wrote a number of articles for the journal. On another visit back to the UK, he married Isabelle Konstam.

Syed Ameer Ali retired in 1904 and settled in the UK. His first task was to launch the London Muslim League (1908) and he took up the issue of Muslim representation. However, he resigned from the Muslim League in 1913 regarding it as too extreme. In 1910, he launched a project to build a mosque in London. And then in 1911 he formed the British Red Crescent Society because the British Red Cross was not helping injured Turks and Arabs in Italian attacks, addressing the need for an independent society to help the sick and wounded irrespective of race or religion. In 1909 he was appointed to the Privy Council, the first Indian member on the Council.

He died on 3 August 1928 at his home, Pollingfold Manor, near Rudgwick, Sussex and was buried in Brockwood Cemetery, Surrey. He had two sons who both studied at Oxford and both eventually retired to settle in Britain with their British wives.